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Updated: Jun 26, 2026

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Published on: February 26, 2017

Aspiration lung disease.

Fernando M de Benedictis¹, Virgilio P Carnielli, Diletta de Benedictis

¹Division of Pediatric Medicine, Department of Pediatrics, Salesi Children's University Hospital, Ancona, Italy. debenedictis@ao-salesi.marche.it

Pediatric Clinics of North America

|January 13, 2009

Summary

This summary is machine-generated.

Diagnosing aspiration lung disease in children remains challenging, often delaying treatment and leading to permanent lung damage. A multidisciplinary approach is crucial for accurate diagnosis and timely care.

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Last Updated: Jun 26, 2026

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

Published on: February 26, 2017

Area of Science:

Pediatric Pulmonology
Gastroenterology
Clinical Medicine

Background:

Aspiration lung disease encompasses a spectrum of clinical syndromes, from massive to chronic aspiration.
Advances in understanding dysphagia, gastroesophageal function, and airway reflexes have been made.
New diagnostic techniques are emerging.

Purpose of the Study:

To highlight the challenges in diagnosing aspiration in children.
To emphasize the need for timely and appropriate care.
To advocate for a multidisciplinary approach.

Main Methods:

Review of current understanding of aspiration mechanisms.
Discussion of diagnostic challenges.
Emphasis on clinical presentation and outcomes.

Main Results:

Characterizing aspiration presence, type, and circumstances in children is extremely difficult.
Many children are diagnosed late, after irreversible lung damage.
Delayed diagnosis and treatment are common.

Conclusions:

A multidisciplinary approach is essential for accurate diagnosis of aspiration lung disease.
Timely and appropriate care is critical to prevent permanent lung damage.
Improved diagnostic strategies are needed for pediatric aspiration.