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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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[Effects by androgen suppression with luteinizing hormone on cognitive functions in men treated for cancer of

C Nedelec1, S Ragot, J Irani

  • 1Service de neurologie, centre hospitalier de la Rochelle, Poitiers, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|January 13, 2009
PubMed
Abstract

Insights

Androgen suppression therapy for prostate cancer did not impair cognitive functions like memory and attention in men. Visual memory and number memory tests showed significant improvements after 12 months of treatment.

Area of Science:

  • Oncology
  • Neuroscience
  • Endocrinology

Background:

  • Prostate cancer treatment often involves androgen suppression therapy.
  • Potential side effects of androgen suppression on cognitive functions require investigation.

Purpose of the Study:

  • To evaluate the impact of androgen suppression on cognitive functions, specifically memory and attention, in men with prostate cancer.

Main Methods:

  • A prospective study involving 18 men treated with luteinizing hormone-releasing hormone (LH-RH) analogues for prostate cancer.
  • Cognitive assessments including Mini Mental State (MMS), memory tests (Grober-Buschke, Rey Test), and attention/executive tests (Trail Making Test, MADRS) were conducted before and at 6 and 12 months post-treatment.

Main Results:

  • 14 patients were eligible for analysis.
  • Visual memory (Rey Test) significantly improved at 6 and 12 months (p<0.001, p<0.02).
  • Inversed number memory (WAIS) also improved after 6 months (p<0.03).

Conclusions:

  • Androgen suppression therapy for prostate cancer did not lead to cognitive impairment over 12 months.
  • Global cognitive performance was preserved, with some aspects of memory showing improvement.
  • Further larger prospective studies are warranted.

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