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Updated: Jun 26, 2026
Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
Prospective cohort study of three- versus two-dimensional ultrasound for prediction of oocyte maturity
Doron Shmorgun1, Edward Hughes, Patrick Mohide
1Department of Obstetrics and Gynecology, Hamilton Health Sciences Corporation and McMaster University, Hamilton, Ontario, Canada.
Objective:
To determine whether three-dimensional follicular ultrasound (3-D) measurements are better predictors of optimal timing of hCG administration than two-dimensional (2-D) images, the current standard.
Design:
Prospective, cohort study.
Setting:
Tertiary referral center.
Patient(S):
Seventy-six patients undergoing IVF.
Intervention(S):
Seventy-six consecutive patients undergoing serial follicular monitoring during IVF had an additional daily 3-D volume scan of their ovaries once lead follicles had reached 16 mm diameter.
Main Outcome Measure(S):
Number of mature oocytes retrieved.
Result(S):
The 2-D follicular diameter measurements predicted 25.4% of the observed variance in the number of mature oocytes retrieved. The 3-D follicular volume measurements were more predictive of outcome, accounting for 29.2% of the observed variance in number of mature oocytes retrieved. Follicles >22 mm diameter and 5 mL volume were associated with fewer mature oocytes reflecting an undesired postmature state. Follicles measuring 11 to 15 mm had a 50% chance of yielding a mature oocyte.
Conclusion(S):
Three-dimensional follicular volume measurements have a stronger correlation with the number of mature oocytes retrieved than 2-D measurements. As 3-D technology improves, this parameter may replace 2-D measurements in the optimal timing of hCG before oocyte retrieval.
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