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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...
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Interactions Between Signaling Pathways

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Related Experiment Video

Updated: Jun 26, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
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An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

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When sirtuins and NF-kappaB collide.

Gioacchino Natoli1

  • 1Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, I-20139 Milan, Italy. gioacchino.natoli@ifom-ieo-campus.it

Cell
|January 13, 2009
PubMed
Summary

Sirtuins and NF-kappaB/Rel transcription factors regulate aging gene expression. SIRT6 in mice dampens NF-kappaB gene expression, linking inflammation, aging, and metabolism.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Sirtuins and NF-kappaB/Rel transcription factors are key regulators of aging-associated gene expression.
  • Understanding the interplay between these factors is crucial for aging research.

Discussion:

  • Kawahara et al. (2009) demonstrate the essential role of the sirtuin SIRT6 in mice.
  • SIRT6 activity is required to suppress NF-kappaB-dependent gene expression.
  • This finding establishes a novel connection between inflammation, aging processes, and metabolic regulation.

Key Insights:

  • SIRT6 acts as a critical suppressor of NF-kappaB signaling in the context of aging.
  • The study highlights a molecular link between inflammatory pathways and aging.
  • This research provides insights into the metabolic consequences of aging-related inflammation.

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Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

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Outlook:

  • Further investigation into SIRT6 function could reveal therapeutic targets for age-related diseases.
  • Exploring the broader implications of the SIRT6-NF-kappaB axis in metabolism is warranted.
  • This work opens new avenues for understanding the complex mechanisms underlying aging and inflammation.