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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Special Staining Techniques01:13

Special Staining Techniques

Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...

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Related Experiment Videos

Coagulase-negative staphylococcal infections.

Kathie L Rogers1, Paul D Fey, Mark E Rupp

  • 1Department of Pathology and Microbiology, University of Nebraska Medical Center, 986280 Nebraska Medical Center, Omaha, NE 68198-6280, USA.

Infectious Disease Clinics of North America
|January 13, 2009
PubMed
Summary

Coagulase-negative staphylococci (CNS) are common skin bacteria. Increased medical device use has led to more significant CNS infections, requiring focus on prevention and management.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Coagulase-negative staphylococci (CNS) are a diverse group of bacteria, distinct from Staphylococcus aureus.
  • Typically commensal organisms on human skin and mucous membranes, CNS are often laboratory contaminants.
  • Recent trends show a rise in clinically significant infections attributed to CNS.

Purpose of the Study:

  • To review the clinical syndromes associated with CNS infections.
  • To discuss the epidemiology and increasing role of CNS in healthcare-associated infections.
  • To outline strategies for the prevention and management of CNS infections.

Main Methods:

  • Literature review of clinical syndromes, epidemiology, and management guidelines.
  • Analysis of the role of indwelling medical devices in CNS pathogenesis.
  • Synthesis of current knowledge on prevention and treatment strategies.

Main Results:

  • CNS infections are increasingly linked to the use of indwelling medical devices.
  • Understanding CNS epidemiology is crucial for effective infection control.
  • Established prevention and management protocols are essential for combating these infections.

Conclusions:

  • CNS have transitioned from common contaminants to significant pathogens, particularly in device-associated infections.
  • Effective prevention and management strategies are vital to address the growing threat of CNS infections.
  • Further research into novel therapeutic and preventative approaches is warranted.