Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Diversity of Protists II

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...

Active versus Passive Immunity

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...

Yellow Fever

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Seeking universal malaria-vaccine targets.

Nature·2026

Same author

First exposure to SARS-CoV-2 shapes IgG subclass switching after mRNA vaccination.

Communications medicine·2026

Same author

Antibody fine specificity correlates with protection from malaria for the RTS,S vaccine in young African children: A post hoc analysis of a phase IIb randomised controlled trial.

PLoS medicine·2026

Same author

DNA methylation and gene expression signatures for common childhood infections.

Clinical epigenetics·2026

Same author

Duration and association with protection of NANP-repeat-specific and C-terminus-specific anti-circumsporozoite protein IgG responses following RTS,S/AS01<sub>E</sub> vaccination: an observational ancillary immunological study of a phase 3 clinical trial.

The Lancet. Infectious diseases·2026

Same author

Relationship between antibody avidity, Fc-mediated functional activity and longevity of malaria vaccine responses in clinical trials.

Frontiers in immunology·2026

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Acquired immunity to malaria.

Denise L Doolan¹, Carlota Dobaño, J Kevin Baird

¹Queensland Institute of Medical Research, The Bancroft Centre, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Denise.Doolan@qimr.edu.au

Clinical Microbiology Reviews

|January 13, 2009

Summary

This summary is machine-generated.

Naturally acquired immunity to Plasmodium falciparum malaria is highly effective in adults and infants. Understanding its mechanisms could lead to better protection for children against severe malaria.

More Related Videos

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Related Experiment Videos

Last Updated: Jun 26, 2026

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Area of Science:

Immunology
Infectious Diseases
Tropical Medicine

Background:

Naturally acquired immunity to Plasmodium falciparum malaria protects millions from severe disease and death.
Current understanding of malaria immunity's onset, determinants, and mechanisms remains incomplete.
Existing knowledge lacks consensus on how acquired immunity to malaria functions.

Purpose of the Study:

To review naturally acquired and experimentally induced immunity against malaria.
To integrate insights from biotechnology with historical, clinical, and epidemiological data.
To advocate for recognizing the high effectiveness of naturally acquired immunity.

Main Methods:

Literature review integrating biotechnology insights.
Analysis of historical, clinical, and epidemiological observations.
Synthesis of current understanding of malaria immunity.

Main Results:

Naturally acquired immunity is nearly 100% effective against severe disease and death in heavily exposed adults.
Immunity in exposed infants can exceed 90% effectiveness against severe outcomes.
Inducing adult-like immunity in high-risk infants could significantly reduce malaria morbidity and mortality.

Conclusions:

Naturally acquired immunity to Plasmodium falciparum is a powerful protective mechanism.
Further research into the mechanisms of adult immunity is crucial for pediatric malaria control.
Duplicating adult immunity in children could drastically diminish severe malaria cases and fatalities.