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Proteomics in gerontology: current applications and future aspects--a mini-review
E Schiffer1, H Mischak, L U Zimmerli
1Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany. schiffer@mosaiques-diagnostics.com
Aging and chronic diseases demand new biomarkers. Proteomics advances offer new diagnostic and therapeutic strategies by analyzing age-related proteomic changes similar to disease patterns.
Area of Science:
- Biomarker discovery
- Proteomics
- Translational medicine
Background:
- Aging is linked to chronic diseases like cancer and cardiovascular disease.
- Novel biomarkers are needed for managing age-related chronic conditions.
Purpose of the Study:
- Review advances in human proteome analysis for biomarkers.
- Discuss technological approaches, their pros and cons.
- Highlight challenges and strategies in clinical proteomics.
Main Methods:
- Analysis of technological approaches in proteomics.
- Review of clinical sample sources.
- Examination of age-related proteomic changes.
Main Results:
- Proteomic changes in aging resemble those in chronic diseases.
- Successful applications of proteomics in disease diagnosis, prognosis, and therapy are demonstrated.
- Technological advancements are driving progress in biomarker discovery.
Conclusions:
- Significant growth in disease-related proteomic data is anticipated.
- Clinical application of proteomics relies on standardized parameters, robust statistics, and collaborative databases.
- The complexity of the proteome necessitates large-scale, collaborative research efforts.
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