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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
Published on: April 4, 2012
Development of imaging methods to assess adiposity and metabolism
1Global Center for Scientific Affairs, Merck & Co., Rahway, NJ, USA. Steven_Heymsfield@Merck.Com
International Journal of Obesity (2005)
|January 13, 2009
Summary
Body composition analysis has evolved from simple models to advanced imaging techniques like computed tomography and MRI. These innovations offer significant promise for future obesity research and understanding human physiology.
Area of Science:
- Physiology
- Metabolism
- Pathological States
Background:
- Early body composition studies utilized a 'two-compartment' model (fat and fat-free mass).
- X-rays were an early method for estimating fat-layer thickness.
Purpose of the Study:
- To review the historical development and technological advancements in body composition studies.
- To highlight the impact of imaging technologies on physiological and metabolic research, particularly in obesity.
Main Methods:
- Historical review of body composition methodologies.
- Introduction of computed tomography (CT) and magnetic resonance imaging (MRI) for in vivo reconstruction.
- Advancements in imaging techniques including functional MRI, diffusion tensor imaging, and PET+CT/MRI.
Main Results:
- Revolutionary advances in imaging enabled complete in vivo reconstruction of body compartments and tissues.
- New research opportunities emerged with the advent of 3D imaging technologies.
- Ongoing methodological refinements continue to expand research capabilities.
Conclusions:
- Imaging technologies have transformed body composition analysis.
- These advanced methods hold significant promise for future obesity research.
- The evolution of body composition studies underscores the importance of technological innovation in scientific discovery.
