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Related Experiment Video

Updated: Jun 26, 2026

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Celecoxib, NSAIDs and the skeleton.

J Patrick O'Connor¹, Thomas Lysz

¹UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA. oconnojp@umdnj.edu

Drugs of Today (Barcelona, Spain : 1998)

|January 13, 2009

Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) impact musculoskeletal healing differently. While beneficial for some injuries like tendon healing and reducing bone growth after hip surgery, chronic use, especially of COX-2 inhibitors, may harm bone healing and density.

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Last Updated: Jun 26, 2026

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

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Published on: January 27, 2023

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Area of Science:

Orthopedics
Pharmacology
Biomedical Engineering

Background:

Musculoskeletal pain management is crucial for recovery from injuries and surgery.
Current treatments include NSAIDs (nonsteroidal anti-inflammatory drugs), COX-2 inhibitors (like celecoxib), and narcotics.
NSAIDs function by inhibiting cyclooxygenase (COX) activity, affecting prostaglandin synthesis involved in pain and inflammation.

Purpose of the Study:

To investigate the multifaceted effects of NSAIDs and COX-2 inhibitors on skeletal tissue healing.
To differentiate the impact of these drugs on various types of musculoskeletal injuries and conditions.

Main Methods:

Review of clinical data and experimental studies on NSAID and celecoxib use in musculoskeletal healing.
Analysis of the role of cyclooxygenase activity and prostaglandin signaling in skeletal repair processes.

Main Results:

NSAID use can negatively affect fracture and tendon-to-bone healing, particularly with COX-2 selective agents.
Chronic celecoxib use may decrease bone mineral density in older males.
NSAIDs can be beneficial in healing tendons by inhibiting adhesions and reducing heterotopic ossification after hip surgery.

Conclusions:

Cyclooxygenase activity is integral to skeletal tissue healing, directly or via inflammation modulation.
NSAID and celecoxib therapy can have varied, sometimes opposing, effects on skeletal healing depending on the tissue and injury type.
Understanding these differential effects is critical for optimizing pain management and recovery in orthopedic patients.