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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Pathophysiology and therapeutic strategies in the management of stroke: an update

Anil Kumar1, Samrita Dogra

  • 1Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chaindigarh, India. kumaruips@yahoo.com

Drugs of Today (Barcelona, Spain : 1998)
|January 13, 2009
PubMed

Insights

Strokes, or brain attacks, are a leading cause of death. While treatments exist, none are curative, highlighting the need for better understanding of stroke neurobiology and improved therapeutic strategies.

Area of Science:

  • Neurology
  • Neuroscience
  • Pathophysiology

Background:

  • Stroke is a leading cause of death and disability globally.
  • Its complex pathophysiology involves excitotoxicity, inflammation, oxidative damage, and ionic imbalances, leading to ischemic neuronal death.
  • Current therapeutic advances, including surgery, thrombolytics, and risk factor management, are not curative.

Purpose of the Study:

  • To summarize recent advances in understanding stroke neurobiology.
  • To provide insights into potential therapeutic strategies for ischemic stroke management.

Main Methods:

  • Review of current literature on stroke pathophysiology and therapeutic interventions.
  • Analysis of recent advancements in neurobiology and treatment approaches.

Main Results:

  • Significant progress has been made in understanding the underlying mechanisms of stroke.
  • Various therapeutic options like carotid endarterectomy, thrombolytics, and neuroprotective agents have been developed.
  • Despite advancements, no current treatment offers a cure for stroke.

Conclusions:

  • Effective management of ischemic stroke requires a deeper understanding of its neurobiology.
  • Further research into novel therapeutic strategies is crucial to reduce the burden of stroke.

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