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Oxymorphone: a mature molecule with new life
1Arizona Research Center, Phoenix, Arizona, USA. jgimbel@azresearch-center.com
Drugs of Today (Barcelona, Spain : 1998)
|January 13, 2009
Summary
Oral oxymorphone hydrochloride offers new pain management options for patients experiencing moderate to severe pain. This review details its pharmacology, efficacy, and tolerability for acute and chronic pain relief.
Area of Science:
- Pharmacology
- Pain Management
- Drug Development
Background:
- Undertreatment of acute and chronic pain is a significant U.S. health issue.
- Opioids are indicated for moderate to severe pain unresponsive to other agents.
- Varied patient responses to opioids necessitate diverse treatment options.
Purpose of the Study:
- To review the pharmacology, clinical efficacy, and tolerability of oral oxymorphone hydrochloride.
- To assess new treatment options for patients with inadequate pain control.
Main Methods:
- Review of pharmacokinetic and pharmacodynamic profiles.
- Analysis of clinical efficacy and tolerability data.
- Evaluation of extended-release and immediate-release oral formulations.
Main Results:
- Oral oxymorphone hydrochloride formulations offer new therapeutic choices.
- Pharmacological data, efficacy, and tolerability are detailed.
- Provides options for patients with suboptimal analgesia from current opioids.
Conclusions:
- Oral oxymorphone hydrochloride represents a valuable addition to pain management strategies.
- Understanding its profile is crucial for optimizing patient care.
- Addresses the need for effective and well-tolerated analgesia.
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