The German Competence Network on Atrial Fibrillation (AFNET)

Area of Science:

• Cardiology
• Clinical Research
• Translational Science

Background:

• Atrial fibrillation (AF) is the most common sustained heart arrhythmia.
• The German Competence Network on Atrial Fibrillation (AFNET) was established to improve AF diagnosis and treatment.
• Patients with AF often present with advanced age and multiple comorbidities.

Purpose of the Study:

• To improve the treatment and management of atrial fibrillation.
• To establish a nationwide patient registry for AF manifestation, diagnostics, and therapy.
• To conduct clinical trials for optimizing pharmacological and non-pharmacological AF treatments.

Main Methods:

• Established a nationwide patient registry in Germany.
• Conducted basic research on AF-induced atrial tissue remodeling.
• Initiated clinical trials including ANTIPAF, Flec-SL, Gap-AF, and BACE-PACE.

Main Results:

• Data indicate high guideline adherence for oral anticoagulation in AF patients.
• Basic research identified therapeutic targets in AF-induced atrial remodeling.
• Clinical trials are investigating novel interventions like angiotensin II receptor blockers and optimized ablation techniques.

Conclusions:

• AFNET plays a crucial role in advancing the understanding and treatment of atrial fibrillation.
• Ongoing research and trials aim to reduce AF recurrence and improve patient outcomes.
• Optimizing anticoagulation and exploring new therapeutic strategies are key focuses.