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Updated: Jun 26, 2026

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat
Published on: February 25, 2020
Limitations of conduits in peripheral nerve repairs
Amy M Moore1, Rahul Kasukurthi, Christina K Magill
1Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Washington University, Campus Box 8238, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Abstract:
Nerve conduits have emerged as alternatives to autologous nerve grafts, but their use in large-diameter nerve deficits remains untested. We report four patients who underwent repair of large-diameter nerves using absorbable nerve conduits and discuss the failed clinical outcomes. The reported cases demonstrate the importance of evaluating the length, diameter, and function of nerves undergoing conduit repair. In large-diameter nerves, the use of conduits should be carefully considered.
