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Related Experiment Video

Updated: Jun 26, 2026

Nerve Stem Cell Differentiation by a One-step Cold Atmospheric Plasma Treatment In Vitro
07:01

Nerve Stem Cell Differentiation by a One-step Cold Atmospheric Plasma Treatment In Vitro

Published on: January 11, 2019

[Tissue engineered nerve based on plasma treatment and BMSCs].

Jia Zhou1, Zunli Shen, Hua Shen

  • 1Department of Plastic Surgery, First Affiliated People's Hospital, Shanghai Jiaotong University, Shanghai 200080, PR China.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|January 14, 2009
PubMed
Summary

Plasma-treated poly(lactic-co-glycolic acid) (PLGA) nerve conduits seeded with bone marrow mesenchymal stem cells (BMSCs) effectively repaired sciatic nerve defects in rats. This approach offers a promising strategy for peripheral nerve tissue engineering.

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Context:

  • Peripheral nerve injuries often result in significant functional deficits.
  • Autologous nerve grafting, the current gold standard, has limitations such as donor site morbidity and limited availability.
  • Tissue-engineered nerve conduits offer a potential alternative for nerve repair.

Purpose:

  • To evaluate the efficacy of plasma-treated poly(lactic-co-glycolic acid) (PLGA) nerve conduits seeded with bone marrow mesenchymal stem cells (BMSCs) in repairing sciatic nerve defects in Sprague-Dawley (SD) rats.

Summary:

  • Sciatic nerve defects in SD rats were reconstructed using plasma-treated PLGA conduits with BMSCs, non-treated PLGA conduits with BMSCs, or autologous nerve grafts.
  • Functional recovery was assessed via walking pattern analysis, sciatic function index (SFI), electrophysiology, and gastrocnemius muscle weight.
  • Histological analysis evaluated regenerated nerve fiber density, diameter, and neural sheath thickness.

Impact:

  • Plasma-treated PLGA conduits seeded with BMSCs demonstrated functional and histological outcomes comparable to autologous nerve grafts, significantly outperforming non-treated conduits.
  • This study highlights the potential of combining plasma treatment with cell-seeded scaffolds for enhanced peripheral nerve regeneration.
  • The findings suggest a novel strategy for developing tissue-engineered nerves to address peripheral nerve defects.