Related Experiment Video
Updated: Jun 26, 2026
Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique
Published on: May 2, 2025
[Progress in genetic modification of vascular prostheses and its significance in molecular reconstruction]
Lingyu Hu1, Zuojun Hu, Shenming Wang
1Department of Vascular Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong 510080, PR China.
Objective:
To summarize the current progress in the genetic modification of vascular prostheses and to look forward to the future of genetic modification in vascular prostheses.
Methods:
PubMed online search with the key words of "vascular prostheses, gene" was undertaken to identify articles about the genetic modification of vascular prostheses. Then these articles were reviewed and summarized.
Results:
To improve long-term patency of vascular prostheses, various genes were transfected into seeded cells. The anti thrombosis activity of local vessels increased.
Conclusion:
Progresses in tissue engineering and molecular biology make possible endothelialization and genetic modification of vascular prostheses. However, because most relevant researches are still basic experiments, further study is needed before clinical application.
