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Updated: Jun 26, 2026

A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes
Published on: February 27, 2017
Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial
Semra Colak1, Christopher F Nelson, Klaus Nüsslein
1Department of Polymer Science and Engineering, University of Massachusetts-Amherst, 120 Governors Drive, Amherst, Massachusetts 01003, USA.
Abstract:
Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).
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