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Published on: March 6, 2019
Hydroxychloroquine-induced hyperpigmentation: a case report
M A Melikoglu1, M Melikoglu, U Gurbuz
1Department of Rheumatology, Physical Medicine and Rehabilitation, School of Medicine, Akdeniz University, Antalya, Turkey. mamelikoglu@gmail.com
Journal of Clinical Pharmacy and Therapeutics
|January 14, 2009
Summary
Antimalarial drugs, including hydroxychloroquine, can cause rare bluish-grey skin discoloration. This report highlights this localized mucocutaneous hyperpigmentation side effect.
Area of Science:
- Pharmacology
- Dermatology
- Rheumatology
Background:
- Antimalarials are widely used for malaria and rheumatoid arthritis.
- These drugs are generally well-tolerated with known side effects.
- Localized mucocutaneous discoloration is an infrequent adverse reaction.
Observation:
- This report focuses on hydroxychloroquine-induced localized mucocutaneous bluish-grey hyperpigmentation.
- A case presentation illustrates this specific side effect.
- The study includes a review of existing literature on the topic.
Findings:
- Hydroxychloroquine can induce localized bluish-grey to black skin and mucous membrane discoloration.
- This finding is based on a case presentation and literature review.
- The adverse reaction is distinct from more common antimalarial side effects.
Implications:
- Clinicians should be aware of this potential side effect of hydroxychloroquine.
- Early recognition can aid in managing patient expectations and treatment.
- Further research may clarify the incidence and mechanisms of this hyperpigmentation.
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