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Related Experiment Video

Updated: Jun 26, 2026

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Hydroxychloroquine-induced hyperpigmentation: a case report.

M A Melikoglu¹, M Melikoglu, U Gurbuz

¹Department of Rheumatology, Physical Medicine and Rehabilitation, School of Medicine, Akdeniz University, Antalya, Turkey. mamelikoglu@gmail.com

Journal of Clinical Pharmacy and Therapeutics

|January 14, 2009

Summary

Antimalarial drugs, including hydroxychloroquine, can cause rare bluish-grey skin discoloration. This report highlights this localized mucocutaneous hyperpigmentation side effect.

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Area of Science:

Pharmacology
Dermatology
Rheumatology

Background:

Antimalarials are widely used for malaria and rheumatoid arthritis.
These drugs are generally well-tolerated with known side effects.
Localized mucocutaneous discoloration is an infrequent adverse reaction.

Observation:

This report focuses on hydroxychloroquine-induced localized mucocutaneous bluish-grey hyperpigmentation.
A case presentation illustrates this specific side effect.
The study includes a review of existing literature on the topic.

Findings:

Hydroxychloroquine can induce localized bluish-grey to black skin and mucous membrane discoloration.
This finding is based on a case presentation and literature review.
The adverse reaction is distinct from more common antimalarial side effects.

Implications:

Clinicians should be aware of this potential side effect of hydroxychloroquine.
Early recognition can aid in managing patient expectations and treatment.
Further research may clarify the incidence and mechanisms of this hyperpigmentation.