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[Routine electron microscopy in the surgical pathology of tumors]
1Oddĕlení patologie Výzkumného ústavu klinické a experimentální onkologie, Brno.
Abstract:
The diagnostic contribution among 35 tumours from Research Institute of Clinical and Experimental Oncology Brno was 62%, 3% of all tumours were examined. The reviewed analogical data are 17-57% and 4-12%. Increased effects is reached by aimed preselection of material. About 5% of all tumours are supposed to be optimal for ultrastructural examination. Broader use of fixation in modified Millonig's solution, especially concerning consultation cases, is recommended.
Insights
Ultrastructural examination of tumors aids diagnosis, with optimal selection improving diagnostic yield. Preselection of cases is crucial for effective ultrastructural analysis in oncology.
Area of Science:
- Oncology
- Pathology
- Electron Microscopy
Context:
- Diagnostic yield of ultrastructural examination in oncology.
- Comparison with existing literature data (17-57% diagnostic contribution).
- Evaluation of 35 tumors from the Research Institute of Clinical and Experimental Oncology Brno.
Purpose:
- To assess the diagnostic contribution of ultrastructural examination.
- To determine the optimal percentage of tumors for ultrastructural analysis.
- To recommend improvements in sample preparation and selection.
Summary:
- The study evaluated 35 tumors, achieving a 62% diagnostic contribution with ultrastructural examination, representing 3% of all examined tumors.
- This yield surpasses reported analogical data (17-57% and 4-12%).
- Aimed preselection of material significantly increases diagnostic effectiveness, with approximately 5% of all tumors deemed optimal for this technique.
Impact:
- Highlights the value of ultrastructural examination in improving diagnostic accuracy for specific tumor types.
- Recommends broader use of modified Millonig's solution fixation, particularly for consultation cases.
- Suggests that optimizing case selection can enhance the diagnostic utility of electron microscopy in oncological research and practice.