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Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
Published on: March 6, 2012
Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select
Ruth A Bryan1, Zewei Jiang, Xianchun Huang
1Departments of Nuclear Medicine,Albert Einstein College of Medicine, Bronx, New York 10461, USA. edadacho@aecom.yu.edu
Antimicrobial Agents and Chemotherapy
|January 14, 2009
Abstract:
We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
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