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Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Related Experiment Video

Updated: Jun 26, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

alpha-Internexin expression identifies 1p19q codeleted gliomas.

F Ducray1, E Crinière, A Idbaih

  • 1Unité INSERM U711, Service de Neurologie Mazarin, CHU Pitié-Salpêtrière, Université Paris VI, France.

Neurology
|January 14, 2009
PubMed
Summary
This summary is machine-generated.

alpha-Internexin (INA) is a reliable prognostic marker for gliomas, particularly oligodendrogliomas. Its expression accurately predicts 1p19q codeletion and improved patient survival, serving as a valuable diagnostic tool.

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Last Updated: Jun 26, 2026

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Area of Science:

  • Neuro-oncology
  • Molecular diagnostics
  • Cancer biomarkers

Background:

  • alpha-Internexin (INA) is a gene encoding a neurofilament protein.
  • INA is upregulated in certain gliomas, especially oligodendrogliomas.

Purpose of the Study:

  • To evaluate alpha-Internexin (INA) expression in gliomas.
  • To correlate INA expression with 1p19q codeletion, a marker for oligodendroglial tumors.
  • To assess INA as a prognostic indicator in gliomas.

Main Methods:

  • Immunohistochemistry used to assess INA expression in 122 gliomas.
  • Correlation analysis performed between INA levels and 1p19q codeletion status.
  • Survival analysis conducted for grade III oligodendroglial tumors.

Main Results:

  • INA expression was detected in 96% of tumors with 1p19q codeletion versus 11% without.
  • INA demonstrated high specificity (86%) and sensitivity (96%) for 1p19q codeletion in oligodendrogliomas.
  • Positive INA expression correlated with significantly longer progression-free and overall survival in grade III oligodendroglial tumors.

Conclusions:

  • alpha-Internexin (INA) expression is a reliable prognostic marker for gliomas.
  • INA serves as a valuable surrogate marker for 1p19q codeletion.
  • INA detection offers a simple method for predicting patient outcomes.