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Updated: Jun 26, 2026

Optimizing Magnetic Force Microscopy Resolution and Sensitivity to Visualize Nanoscale Magnetic Domains

Optimizing Magnetic Force Microscopy Resolution and Sensitivity to Visualize Nanoscale Magnetic Domains

Published on: July 20, 2022

Nanoscale magnetic resonance imaging.

C L Degen¹, M Poggio, H J Mamin

¹IBM Research Division, Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.

Proceedings of the National Academy of Sciences of the United States of America

|January 14, 2009

Summary

We developed nanoscale magnetic resonance force microscopy (MRFM) for 3D imaging. This technique achieves sub-10 nm resolution, a 100 million-fold improvement over conventional magnetic resonance imaging (MRI).

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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

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Published on: December 9, 2010

Area of Science:

Physics
Materials Science
Biophysics

Background:

Conventional magnetic resonance imaging (MRI) lacks the resolution for nanoscale investigations.
Nanoscale imaging requires techniques capable of probing materials at the sub-10 nm level.

Purpose of the Study:

To develop a 3D imaging technique with sub-10 nm resolution.
To demonstrate the capability of magnetic resonance force microscopy (MRFM) for nanoscale imaging.

Main Methods:

Combined ultrasensitive magnetic resonance force microscopy (MRFM) with 3D image reconstruction.
Utilized the "resonant slice" principle for projecting nuclear spin density from a nanoscale magnetic tip.
Applied the technique to image proton (1H) spin density in biological samples.

Main Results:

Achieved magnetic resonance imaging (MRI) resolution below 10 nm.
Successfully imaged the 1H spin density within individual tobacco mosaic virus particles.
Demonstrated a 100 million-fold improvement in volume resolution compared to conventional MRI.

Conclusions:

MRFM combined with 3D reconstruction offers unprecedented resolution for nanoscale imaging.
The technique is capable of 3D, elementally selective imaging at the nanometer scale.
This advancement opens new avenues for studying materials and biological structures at the nanoscale.