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Updated: Jun 26, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Novel class of hybrid natural products as antidiabetic agents
Kanwal Raj1, Namita Misra, Geetali Pachauri
1Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow, India. kanwalraj12@rediffmail.com
Abstract:
A number of O-alkylated xanthone, carbazoles and coumarins have been synthesised and screened for their in vitro anti-diabetic activity, such as glucose-6-phosphatase, glycogen phosphorylase and alpha glucosidase inhibitors. Compounds which were showing significant percentage inhibition were also tested for in vivo anti-hyperglycemic activity in sucrose loaded normal and streptozotocin (STZ)-induced diabetic rats. These compounds show 22.1, 24.4 and 26.7% and 20.8, 25.0, 20.5% lowering in sucrose loaded normal rats and STZ-induced diabetic rats at a dose of 100 mg kg(-1).
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