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[A pathohistological study on experimental brucellosis in inbred mice]
1Laboratory of Pathology, Professional Medical Research Institute of Coal Ministry, Beijing.
Abstract:
A pathohistological study was carried out in BALB/C and C57/BL inbred mice models infected with B. melitensis, B. abortus, and B. suis respectively. The results showed that a chronic pathological lesion was developed due to repeated infectious processes occurred in various organs at different stages of brucella infection. Significant pathological changes was observed in the reticuloendothelial system including the lymphocytes, spleen and liver etc. and less remarkable changes were seen in the lung, heart and kidney in sequence. Comparing the pathological changes induced by the three species of brucella infection, lesions developed in BALB/C was more remarkable and the pathological change induced by B. abortus infection was the most significant in both BALB/C and C57/BL mice.
Insights
Brucella infection causes chronic lesions, particularly in the reticuloendothelial system. B. abortus infection induced the most significant pathological changes in both BALB/C and C57/BL mice.
Area of Science:
- Pathology
- Infectious Diseases
- Immunology
Background:
- Brucellosis is a significant zoonotic disease caused by Brucella species.
- Understanding the pathological progression and host response is crucial for disease management.
- Inbred mouse models are vital for studying infectious diseases.
Purpose of the Study:
- To investigate the pathohistological changes induced by different Brucella species in BALB/C and C57/BL mice.
- To compare the severity of lesions caused by B. melitensis, B. abortus, and B. suis.
- To identify key organs affected during chronic brucellosis.
Main Methods:
- BALB/C and C57/BL inbred mice were infected with B. melitensis, B. abortus, and B. suis.
- Pathohistological examination of various organs was performed at different stages of infection.
- Comparative analysis of pathological changes between mouse strains and Brucella species.
Main Results:
- Chronic pathological lesions developed in multiple organs due to repeated infectious processes.
- Significant changes were observed in the reticuloendothelial system (lymphocytes, spleen, liver).
- B. abortus infection caused the most significant pathological changes in both mouse models, with BALB/C mice showing more remarkable lesions overall.
Conclusions:
- Brucella infection leads to chronic, progressive pathological changes, primarily affecting the reticuloendothelial system.
- B. abortus is identified as inducing the most severe pathology among the tested species.
- Host genetic background (BALB/C vs. C57/BL) influences the severity of Brucella-induced lesions.
