[Treatment of breast proliferation disease with modified xiao yao san and er chen decoction]

The authors report the 3 months' treatment of 51 cases of breast proliferation disease with modified Xiao Yao San and Er Chen decoction, an effective rate being 96.1%. In each patient before and after treatment, saliva estradiol (SE2), saliva progesterone (SP), saliva testosterone (ST) and plasma prolactin (PRL) concentrations were monitored and breast molybdenum-target X-ray films were taken. The results showed that after treatment, SE2 concentrations declined very significantly (P less than 0.001); SP concentrations declined significantly (P less than 0.05); PRL concentrations declined very significantly (P less than 0.005), but ST concentrations did not change significantly. Breast molybdenum-target X-ray films showed absorption of proliferation masses in 21 cases. These indicated that the medicine could regulate endocrine system, perhaps through suppressing secretion of PRL, decreasing prolactin antagonist action to follicular stimulating hormone so as to restore follicle function, and could regulate pituitary-follicle axis and make the axis normal.