[Cytochrome P450 2E1 expression in mice liver after exposure to continuous and acute gamma-radiation]

The effect of continuous low-intensity and acute high-intensity ionizing radiation in low and high doses on expression of cytochrome P450 2El (1.14.14.1) in mice liver was studied. It was shown, that changes of Cyp2e1 amount depended on the dose and intensity of ionizing radiation. Low doses of continuous gamma-radiation caused reliable decrease of Cyp2e1 expression on protein mRNA levels. Low doses of acute gamma-radiation lead to an increase of Cyp2el amount, while high doses--to a corresponding decrease. We showed, that low and high doses of acute gamma-radiation caused a significant decrease of Cyp2e1 mRNA level. We suppose that the detected changes of Cyp2el expression are associated with peroxidation process and development of oxidative stress.