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Updated: Jun 26, 2026

Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
Published on: November 21, 2017
Connecting irreversible to reversible aggregation: time and temperature
S Corezzi1, C De Michele, E Zaccarelli
1CNR-INFM Polylab, CNR-INFM Polylab, Largo Pontercorvo 3, I-56127 Pisa, Italy.
Abstract:
We report molecular dynamics simulations of a gel-forming mixture of ellipsoidal patchy particles with different functionality. We show that in this model, which disfavors the formation of bond-loops, elapsed time during irreversible aggregation--leading to the formation of an extended network--can be formally correlated with equilibrium temperature in reversible aggregation. We also show that it is possible to develop a parameter-free description of the self-assembly kinetics, bringing reversible and irreversible aggregation of loopless branched systems to the same level of understanding as equilibrium polymerization.
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