Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Smart Catheters for Diagnosis, Monitoring, and Therapy.

Advanced healthcare materials·2025

Same author

Advances in biosensors for diagnosis of Alzheimer's and Parkinson's diseases.

Biosensors & bioelectronics·2025

Same author

Author Correction: Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells.

Nature biotechnology·2025

Same author

Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance.

Photochemistry and photobiology·2024

Same author

Forty years of advances in optical biosensors-are "autonomous" biosensors in our future?

Analytical and bioanalytical chemistry·2024

Same author

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs.

Frontiers in pharmacology·2024

Same journal

Modeling the Effects of Short-Range Randomness in Packed Sphere Beds.

Analytical chemistry·2026

Same journal

Mitochondrial Redox Cascade-Directed Covalent NIR Fluorogenic Imaging of Therapy-Induced Senescence Integrates Tumor and Host Responses.

Analytical chemistry·2026

Same journal

Proteomic Profiling of RHD-Related Mitral Annulus Calcification Enabled by Magnetic Carbon Nanomaterial-Supported Quasi-Immobilized Enzyme Digestion.

Analytical chemistry·2026

Same journal

Spatial-Photonic Encoding on a Single Fiber: Breaking the Bottleneck in Photoelectrochemical Biosensing for Precision Diagnostics.

Analytical chemistry·2026

Same journal

Spreadable Biosensing Pregel for Analyte Visualization in Peeled Plant Tissues.

Analytical chemistry·2026

Same journal

DARibo-Q: RNA Allosteric Transduction for Fluorescence Imaging of Dopamine Modulation in Living Systems.

Analytical chemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Published on: April 17, 2017

Perspective on optical biosensors and integrated sensor systems.

Frances S Ligler¹

¹Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, 455 Overlook Avenue South West, Washington, DC 20375, USA.

Analytical Chemistry

|January 15, 2009

Summary

This summary is machine-generated.

Optical biosensors are advancing from labs to real-world applications. Innovations in molecular recognition, microfluidics, and fabrication promise smaller, faster, and cheaper systems for public health and environmental monitoring.

More Related Videos

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Published on: November 20, 2013

Related Experiment Videos

Last Updated: Jun 26, 2026

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

Published on: April 17, 2017

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Published on: November 20, 2013

Area of Science:

Biotechnology
Sensor Technology
Optics

Background:

Optical biosensors are transitioning from laboratory research to practical, point-of-use applications.
The adoption of sensor technology for public health and environmental monitoring is increasing.

Purpose of the Study:

To identify innovations driving the development of advanced optical biosensor systems.
To highlight the potential for improved public health and environmental monitoring through sensor technology.

Main Methods:

Review of emerging concepts in molecular recognition.
Analysis of integrated microfluidics and optics in biosensor design.
Assessment of simplified fabrication and system integration approaches.

Main Results:

Identification of key innovations enabling smaller, faster, and more cost-effective optical biosensors.
Demonstration of the potential for actionable data generation from these advanced systems.

Conclusions:

Technological advancements are accelerating the deployment of optical biosensors.
These next-generation biosensors will significantly enhance public health and environmental monitoring capabilities.