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Frequency of microemboli signal in stroke patients treated with low molecular weight heparin or aspirin

Qing Hao1, Hui Meng Chang, Meng Cheong Wong

  • 1Department of Medicine &Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|January 15, 2009
PubMed
Abstract

Insights

Microemboli signals (MES) in stroke patients did not differ significantly between those treated with low molecular weight heparin (LMWH) and aspirin. Transcranial Doppler (TCD) monitoring showed similar MES frequencies, indicating comparable embolic phenomena in both treatment groups.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Microemboli signals (MES) detected via transcranial Doppler (TCD) indicate ongoing embolic phenomena.
  • MES presence predicts recurrent stroke or transient ischemic attack.
  • Large artery occlusive diseases are a significant cause of stroke.

Purpose of the Study:

  • To investigate the frequency of MES in stroke patients with large artery occlusive diseases.
  • To compare MES frequency between patients treated with low molecular weight heparin (LMWH) and aspirin.

Main Methods:

  • Patients from the Fraxiparine in Ischemic Stroke (FISS)-tris study were analyzed.
  • MES detection was performed using transcranial Doppler (TCD) on days 1, 3, and 7 post-randomization.
  • The chi-squared test was used to determine the correlation between MES presence and treatment allocation.

Main Results:

  • No significant difference in MES detection rates between LMWH and aspirin groups on days 1 (P=.475), 3 (P=.821), and 7 (P=.938).
  • Median MES counts showed no significant variations between the LMWH and aspirin groups across the study days.
  • The study included 47 patients, with 26 randomized to LMWH and 21 to aspirin.

Conclusions:

  • Treatment with LMWH or aspirin did not result in a significant difference in MES frequency.
  • This suggests comparable management of embolic phenomena in large artery occlusive disease stroke patients treated with LMWH versus aspirin.

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