Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Cardiac Catheterization III: Left Heart Catheterization

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Heart Failure IV: Classification and Diagnostic Evaluation

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diagnosis-to-Ablation Time and Atrial Arrhythmia Recurrence After Ablation.

JAMA network open·2026

Same author

Early Safety Profile Using Pulsed Field Ablation: Prospective Multicenter DISRUPT-AF Study.

JACC. Clinical electrophysiology·2026

Same author

Patient Characteristics and Utilization Patterns of Ambulatory Atrial Fibrillation Ablation in the United States.

JACC. Advances·2026

Same author

Ventricular tachycardia ablation associated abnormalities on FDG PET/CT in patients with suspected cardiac sarcoidosis.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026

Same author

Establishing and managing a mortality and morbidity program in the electrophysiology lab: An essential component of quality.

Heart rhythm·2025

Same author

Association of Dialysate Bicarbonate with Arrhythmia in the Monitoring in Dialysis Study.

Kidney360·2024

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

ICD Implantation in Patients With Ischemic Left Ventricular Dysfunction.

Jaydutt B Patel¹, Bruce A Koplan

¹Jaydutt B. Patel, MD Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. jbpatel@partners.org.

Current Treatment Options in Cardiovascular Medicine

|January 15, 2009

Summary

Sudden cardiac death (SCD) remains a leading cause of heart disease mortality. Current risk assessment for implantable cardioverter-defibrillator (ICD) therapy using left ventricular ejection fraction is insufficient, necessitating improved strategies for patient selection.

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Related Experiment Videos

Last Updated: Jun 26, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Area of Science:

Cardiology
Electrophysiology
Preventive Medicine

Background:

Sudden cardiac death (SCD) accounts for the majority of heart disease-related fatalities.
Risk stratification in ischemic heart disease aims to identify individuals who could benefit from an implantable defibrillator.
Left ventricular ejection fraction is the primary clinical metric for selecting patients for primary prevention implantable cardioverter-defibrillator (ICD) therapy.

Purpose of the Study:

To highlight the limitations of current risk stratification methods for sudden cardiac death.
To emphasize the need for improved patient selection for implantable cardioverter-defibrillator (ICD) therapy.
To advocate for further research into more accurate risk assessment tools.

Main Methods:

Review of current clinical practices in sudden cardiac death risk stratification.
Analysis of the efficacy of left ventricular ejection fraction in predicting sudden cardiac death.
Identification of gaps in current risk assessment protocols.

Main Results:

Many sudden cardiac deaths occur in patients lacking traditional high-risk indicators.
A significant number of patients receiving implantable cardioverter-defibrillators (ICDs) do not experience device therapy activation.
Existing risk stratification methods demonstrate suboptimal accuracy.

Conclusions:

Current methods for selecting patients for implantable cardioverter-defibrillator (ICD) therapy are inadequate.
There is a critical need to develop and validate novel risk stratification tools.
Improved patient selection will optimize the use of defibrillator therapy and reduce sudden cardiac death.