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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
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Updated: Jun 26, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Reversible dilated cardiomyopathy associated with post-partum thyrotoxic storm.

M J Daly1, C M Wilson, S J Dolan

  • 1Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.

QJM : Monthly Journal of the Association of Physicians
|January 15, 2009
PubMed
Summary

A rare, life-threatening complication of thyrotoxicosis occurred in a young mother postpartum. This case highlights thyrotoxic storm with severe cardiac issues, including dilated cardiomyopathy and ventricular fibrillation.

Related Experiment Videos

Last Updated: Jun 26, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Area of Science:

  • Cardiology
  • Endocrinology
  • Obstetrics

Background:

  • Thyrotoxicosis, a common endocrine disorder, can present with various complications.
  • Thyrotoxic heart disease is a known manifestation, but severe postpartum presentations are rare.

Observation:

  • A young mother developed postpartum pulmonary edema.
  • The patient presented with symptoms indicative of thyrotoxic storm.

Findings:

  • The case involved a rare instance of thyrotoxic storm in the postpartum period.
  • This was associated with dilated cardiomyopathy, congestive cardiac failure, and ventricular fibrillation.

Implications:

  • This case underscores the potential for severe, life-threatening cardiac complications of thyrotoxicosis during the postpartum period.
  • Early recognition and management of thyrotoxic storm in postpartum women are critical for preventing fatal outcomes.