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Updated: Jun 26, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
Published on: December 21, 2018
How to test brain and brain simulant at ballistic and blast strain rates
Jiangyue Zhang1, Bo Song, Frank A Pintar
1Department of Neurosurgery, Medical College of Wisconsin, VA Medical Center, Milwaukee, WI, USA.
Abstract:
Mechanical properties of brain tissue and brain simulant at strain rate in the range of 1000 s-1 are essential for computational simulation of intracranial responses for ballistic and blast traumatic brain injury. Testing these ultra-soft materials at high strain rates is a challenge to most conventional material testing methods. The current study developed a modified split Hopkinson bar techniques using the combination of a few improvements to conventional split Hopkinson bar including: using low impedance aluminum bar, semiconductor strain gauge, pulse shaping technique and annular specimen. Feasibility tests were conducted using a brain stimulant, Sylgard 527. Stress-strain curves of the simulant were successfully obtained at strain rates of 2600 and 2700 s-1 for strain levels up to 60%. This confirmed the applicability of Hopkinson bar for mechanical properties testing of brain tissue in the ballistic and blast domain.
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