Threedimensional eeg source reconstruction on high performance computers methodological and computational issues

This paper presents an original problem solving framework specifically conceived and designed to achieve high performance three-dimensional (3D) reconstruction of the sources of electroencephalographic (EEG) brain activity, named TEBAM (True Electrical Brain Activity Mapping). We describe the integrated framework that has been proposed and developed, specifying TEBAM's design characteristics, implementation and tools interconnections (pipelines). TEBAM relays on patient's specific realistic head modeling for the EEG forward and inverse problem evaluation and is implemented and optimized with a very flexible approach to solve in short time, by means of High Performance Computing resources, the large scale computations needed. Results of 3D True Electrical Brain Activity Mapping can be visualized in TEBAM framework in different multimodal ways, combining the anatomical information with the computed results to give an optimal insight of computation output, relying also on stereographic visualization.