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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Videos

Correlation between corneal and scleral thickness in glaucoma.

Jelinar Mohamed-Noor1, Frank Bochmann, Muhammad Abdul Rehman Siddiqui

  • 1Department of Ophthalmology, Aberdeen Royal Infirmary and University of Aberdeen, Aberdeen, UK. JelinarMNoor@hotmail.com

Journal of Glaucoma
|January 15, 2009
PubMed
Summary

A correlation between central corneal thickness and anterior scleral thickness exists in normal tension glaucoma patients. However, no such correlation was found in primary open-angle glaucoma, ocular hypertension, or control groups.

Related Experiment Videos

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Corneal and Scleral Biomechanics

Background:

  • Glaucoma encompasses a group of optic neuropathies characterized by progressive damage.
  • Central corneal thickness (CCT) and anterior scleral thickness (ST) are key ocular biometrics.
  • Understanding the relationship between CCT and ST is crucial for glaucoma diagnosis and management.

Purpose of the Study:

  • To investigate the correlation between central corneal thickness (CCT) and anterior scleral thickness (ST).
  • To compare this correlation across different glaucoma subtypes: primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and ocular hypertension (OHT), as well as normal individuals.

Main Methods:

  • A cohort of 124 subjects including patients with OHT, POAG, NTG, and healthy controls were recruited.
  • Central corneal thickness (CCT) was measured using ultrasonic pachymetry.
  • Anterior scleral thickness (ST) was measured via ultrasonic biomicroscopy at the temporal quadrant, 2 mm posterior to the scleral spur.

Main Results:

  • Central corneal thickness was significantly higher in the OHT group compared to POAG and NTG groups.
  • Anterior scleral thickness was significantly greater in the OHT group than in the NTG group.
  • A significant positive correlation between CCT and ST was observed exclusively in the NTG subgroup (r=0.440, P=0.013).

Conclusions:

  • A correlation between central corneal thickness and anterior scleral thickness is present in patients with normal tension glaucoma.
  • No significant correlation between CCT and ST was found in patients with ocular hypertension, primary open-angle glaucoma, or in the control group.