Related Experiment Video
Updated: Jun 26, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[An update on the debate about the genetic or environmental nature of psychiatric disorders]
1Instituto de Investigaciones Farmacológicas (ININFA). vigo.daniel@gmail.com
Abstract:
During part of the past century any reference to genetics as cause for psychiatric disorders was vetoed, favouring explanations based on the environment as pathogen. Later and as a backlash, science seemed to bet on the sufficiency of the genetic level to understand pathology. Currently, in keeping with the consolidation of the neuroscientific paradigm, a higher level of complexity has been achieved and has rendered new models, such as gene-environment interaction and correlation, which allow for a more rigorous understanding of how the human phenotype displays itself in the world. Profound transformations in the field of mental health can be foreseen as a result of the new paradigm.
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
