Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cellular Adaptation IV: Dysplasia and Metaplasia

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

External Female Genitals

External Female Genitals

The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more pigmented, and hairless. While the...

Classification of Epithelial Tissues: Stratified Epithelium

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...

Classification of Epithelial Tissues: Overview

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of the transition to HPV-based primary screening in Portugal's organized cervical cancer screening program: A controlled interrupted time-series analysis (2014-2023).

Public health in practice (Oxford, England)·2026

Same author

Abnormal uterine bleeding as a presenting symptom is related to multiple uterine leiomyoma: an ultrasound-based study.

International journal of women's health·2013

Same author

Positive association of polymorphisms in estrogen biosynthesis gene, CYP19A1, and metabolism, GST, in breast cancer susceptibility.

DNA and cell biology·2012

Same author

Smoking and cervical cancer.

ISRN obstetrics and gynecology·2011

Same author

Glutathione S-transferase M1, T1, and P1 genotypes and breast cancer risk: a study in a Portuguese population.

Molecular and cellular biochemistry·2011

Same author

Recurrent vulvar cancer.

Clinical obstetrics and gynecology·2005

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Vulvar intraepithelial neoplasia: a current problem].

José Alberto Fonseca-Moutinho¹

¹Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal. jafmoutinho@mail.telepac.pt

Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia

|January 15, 2009

Summary

Vulvar intraepithelial neoplasia (VIN) is a growing concern, particularly in young women. Early detection through biopsies and understanding risk factors like HR-HPV are crucial for managing this condition and preventing vulvar cancer.

More Related Videos

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Related Experiment Videos

Last Updated: Jun 26, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia

Published on: February 16, 2024

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Area of Science:

Gynecologic pathology
Oncology
Infectious disease

Context:

Vulvar intraepithelial neoplasia (VIN) is a recognized pathological entity with increasing incidence, especially among younger women.
VIN is classified into usual (warty, basaloid, mixed) and differentiated types.
High-risk human papillomavirus (HR-HPV) infection is a significant risk factor, alongside HIV, smoking, and other intraepithelial neoplasias.

Purpose:

To define Vulvar intraepithelial neoplasia (VIN) and its classification.
To identify risk factors associated with VIN development.
To outline diagnostic, therapeutic, and follow-up strategies for VIN.

Summary:

VIN is a heterogeneous vulvar lesion with increasing incidence, linked to HR-HPV infection.
Diagnosis requires colposcopy-guided biopsies, as symptoms are non-specific.
Standard treatments like surgical excision and laser CO2 vaporization have high recurrence rates, necessitating close patient follow-up.

Impact:

VIN diagnosis indicates an elevated risk of developing invasive vulvar cancer.
Topical imiquimod shows promise as a treatment option.
Prophylactic HR-HPV vaccination is anticipated to be a key preventive measure against VIN.