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Development of tolerance to kava in mice
1School of Physiology and Pharmacology, University of NSW, Kensington, Australia.
Clinical and Experimental Pharmacology & Physiology
|August 1, 1991
Summary
Mice rapidly developed tolerance to kava
Area of Science:
- Pharmacology
- Neuroscience
Background:
- Kava is a traditional beverage with psychoactive properties.
- The development of tolerance to kava's effects is not well understood.
Purpose of the Study:
- To investigate the development of physiological and learned tolerance to kava extracts in mice.
Main Methods:
- Mice were administered aqueous kava extract or lipid-soluble kava resin.
- Tolerance was assessed by observing changes in behavior and motor control.
- Different dosing regimens and administration routes were employed.
Main Results:
- Rapid physiological tolerance developed to the aqueous kava extract.
- Kava resin showed slower tolerance development, with partial tolerance observed under specific high-dose conditions.
- Learned tolerance was not induced in mice even with daily administration of kava resin.
Conclusions:
- Tolerance to kava's effects varies depending on the extract type and administration method.
- Inducing physiological or learned tolerance to kava resin in mice appears challenging.