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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jun 26, 2026

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

Angiogenesis after cerebral ischemia.

Heike Beck¹, Karl H Plate

¹Institute of Cardiovascular Physiology, Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians University Munich, Marchioninistr. 27, 81377, Munich, Germany. Heike.Beck@med.uni-muenchen.de

Acta Neuropathologica

|January 15, 2009

Summary

Brain ischemia triggers new blood vessel growth (angiogenesis) to aid recovery. Understanding these mechanisms is key for developing new stroke treatments, despite potential risks from growth factors.

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Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Published on: March 1, 2019

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Last Updated: Jun 26, 2026

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

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Published on: June 22, 2022

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Published on: March 1, 2019

Area of Science:

Neuroscience
Vascular Biology
Regenerative Medicine

Background:

The adult brain vasculature is typically stable.
Brain ischemia induces endothelial cell proliferation and angiogenesis, especially at the ischemic boundary zone.
Angiogenesis enhances oxygen and nutrient supply, supporting neurogenesis and synaptogenesis for functional recovery.

Purpose of the Study:

To review the molecular mechanisms of angiogenesis following cerebral ischemia.
To discuss therapeutic strategies for stimulating post-ischemic angiogenesis in stroke treatment.

Main Methods:

Literature review of molecular mechanisms of angiogenesis post-cerebral ischemia.
Discussion of experimental, pharmacological, and cellular approaches to enhance angiogenesis.

Main Results:

Cerebral ischemia activates angiogenesis, primarily in the ischemic boundary zone.
New blood vessels improve tissue supply and facilitate neurorestorative processes.
Certain growth factors involved in angiogenesis can increase vascular permeability, posing potential risks.

Conclusions:

Understanding the molecular basis of post-ischemic angiogenesis is crucial for stroke therapy development.
Targeting angiogenesis offers therapeutic potential, but careful consideration of adverse effects is necessary.
Experimental approaches show promise for enhancing beneficial angiogenesis after stroke.