Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Different Anti-Hyperglycaemic Treatments on Bone Turnover Markers and Bone Mineral Density in Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis.

International journal of molecular sciences·2024
Same author

Bone Mineral Density Response to Long-Term Bisphosphonate Treatment and Discontinuation in a Real-World Clinical Service.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2023
Same author

Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status.

Journal of osteoporosis·2016
Same author

We are what we eat--is it time to reconsider calcium-deficiency rickets in Nigeria? (FA).

Tropical medicine & international health : TM & IH·2014
Same author

Health-related quality of life in women referred for bone density assessment: relationships with bone mineral density, fracture and co-morbidity.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2014
Same author

Application of sub-regional analysis to bone mineral density of the lower limb from whole body DXA scans.

Physiological measurement·2013

Related Experiment Video

Updated: Jun 26, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Bone resorption in stroke and institutionalized subjects.

Michael J Haddaway1, Natalie J Bainbridge, Diane E Powell

  • 1Charles Salt Centre for Human Metabolism, Robert Jones & Agnes Hunt Orthopaedic NHS Trust, Oswestry, Shropshire SY107AG, UK. mike.haddaway@rjah.nhs.uk

Calcified Tissue International
|January 15, 2009
PubMed
Summary

Stroke patients experience early bone resorption, increasing hip fracture risk. Early interventions to reduce bone loss are recommended, especially for those with lower mobility post-stroke.

More Related Videos

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
10:39

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology

Published on: December 7, 2011

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Related Experiment Videos

Last Updated: Jun 26, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
10:39

Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology

Published on: December 7, 2011

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

  • Gerontology
  • Orthopedics
  • Neurology

Background:

  • Stroke survivors have an increased risk of hip fracture, particularly on the affected side.
  • The early onset and relationship between bone loss, immobility, and stroke are not well understood.

Purpose of the Study:

  • To investigate early bone resorption markers in stroke patients.
  • To correlate bone resorption with bone density and mobility in older adults post-stroke.

Main Methods:

  • Measured urinary cross-linked N telopeptide of type I collagen (uNTx) and urinary calcium (log-transformed and creatinine-corrected) in stroke patients and two control groups (healthy and institutionalized).
  • Assessed heel bone mineral density (BMD), Tinetti mobility scores, and prestroke Barthel function scores.
  • Analyzed relationships between bone resorption markers, BMD, and mobility levels.

Main Results:

  • Bone resorption (log uNTx/Cr) was elevated in stroke patients compared to healthy controls, particularly in those with lower mobility (lowest Tinetti tertile).
  • Inverse relationship observed between bone resorption and BMD in female controls and male stroke patients.
  • Higher bone resorption noted in stroke patients with lower prestroke functional status (Barthel index ≤ 17).

Conclusions:

  • Bone resorption begins early after stroke, contributing to increased hip fracture risk.
  • Reduced mobility post-stroke is associated with heightened bone resorption.
  • Early therapeutic strategies to mitigate bone resorption in stroke survivors are warranted.