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Quetiapine dosage across diagnostic categories
Yasser Khazaal1, Anne Chatton, Riaz Khan
1Division of Substance Abuse, Geneva University Hospitals, Rue Verte 2, 1205 Geneva, Switzerland. yasser.khazaal@hcuge.ch
The Psychiatric Quarterly
|January 15, 2009
Summary
This study found that quetiapine, an antipsychotic medication, is prescribed at lower doses for patients with personality disorders compared to those with psychotic disorders. Dosing varied across different psychiatric conditions.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Quetiapine is an atypical antipsychotic used for various psychiatric conditions.
- Understanding quetiapine dosage patterns across diagnoses is crucial for optimizing treatment.
Purpose of the Study:
- To analyze quetiapine dosage variations among psychiatric inpatients with different diagnoses.
- To identify factors influencing high-dose quetiapine prescription.
Main Methods:
- Retrospective review of 231 adult inpatients' discharge records (1999-2005).
- Logistic regression analysis to correlate quetiapine dosage (≥800 mg/day vs. <800 mg/day) with diagnostic category, substance abuse, benzodiazepine use, age, and sex.
Main Results:
- Patients with personality disorders were significantly less likely to receive high-dose quetiapine (≥800 mg/day) compared to those with psychotic disorders (OR=0.1, P=0.007).
- Quetiapine was prescribed across diverse diagnostic groups including psychotic disorders, personality disorders, bipolar disorders, and depression/anxiety disorders.
Conclusions:
- Quetiapine is utilized in a broad spectrum of psychiatric conditions.
- Prescribed quetiapine dosages differ significantly based on patient diagnosis, notably lower for personality disorders.
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