Virtual trabecular bone models and their mechanical response

The study of the mechanical behaviour of trabecular bone has extensively employed micro-level finite element (microFE) models generated from images of real bone samples. It is now recognized that the key determinants of the mechanical behaviour of bone are related to its micro-architecture. The key indices of micro-architecture, in turn, depend on factors such as age, anatomical site, sex, and degree of osteoporosis. In practice, it is difficult to acquire sufficient samples that encompass these variations. In this preliminary study, a method of generating virtual finite element (FE) samples of trabecular bone is considered. Virtual samples, calibrated to satisfy some of the key micro-architectural characteristics, are generated computationally. The apparent level elastic and post-elastic mechanical behaviour of the generated samples is examined: the elastic mechanical response of these samples is found to compare well with natural trabecular bone studies conducted by previous investigators; the post-elastic response of virtual samples shows that material non-linearities have a much greater effect in comparison with geometrical non-linearity for the bone densities considered. Similar behaviour has been reported by previous studies conducted on real trabecular bone. It is concluded that virtual modelling presents a potentially valuable tool in the study of the mechanical behaviour of trabecular bone and the role of its micro-architecture.