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Related Concept Videos

Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
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Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 26, 2026

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

ESCRTs and human disease.

Suraj Saksena1, Scott D Emr

  • 1Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, 441 Weill Hall, Cornell University, Ithaca, NY 14853, USA.

Biochemical Society Transactions
|January 16, 2009
PubMed
Summary
This summary is machine-generated.

The endosomal sorting complex required for transport (ESCRT) machinery is vital for cellular processes. This review highlights ESCRT

Related Experiment Videos

Last Updated: Jun 26, 2026

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The endosomal sorting complex required for transport (ESCRT) machinery is essential for regulating protein trafficking.
  • ESCRT components are conserved across eukaryotic organisms, indicating fundamental biological roles.
  • Dysregulation of ESCRT function is implicated in various cellular abnormalities.

Purpose of the Study:

  • To review the established and emerging connections between ESCRT-mediated protein sorting and human diseases.
  • To provide an overview of the ESCRT pathway's involvement in multivesicular body (MVB) formation and function.
  • To synthesize current knowledge on how ESCRT dysfunction contributes to pathological conditions.

Main Methods:

  • Literature review of studies investigating ESCRT function.
  • Analysis of research linking ESCRT pathway components to specific human diseases.
  • Synthesis of findings related to receptor down-regulation and viral budding processes.

Main Results:

  • The ESCRT machinery is crucial for receptor down-regulation and viral particle release.
  • Aberrant ESCRT pathway activity is associated with diverse human pathologies.
  • Specific ESCRT components are implicated in diseases ranging from cancer to neurodegenerative disorders.

Conclusions:

  • The ESCRT pathway is a significant player in maintaining cellular homeostasis.
  • Understanding ESCRT-MVB pathway links offers potential therapeutic targets for human diseases.
  • Further research into ESCRT functions can elucidate disease mechanisms and inform treatment strategies.