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Related Experiment Video

Updated: Jun 26, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

When pain after surgery doesn't go away...

Siún Burke1, George D Shorten

  • 1Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland.

Biochemical Society Transactions
|January 16, 2009
PubMed
Summary
This summary is machine-generated.

Chronic post-surgical pain, a widespread issue from nerve injury, can be prevented with minimally invasive surgery and multimodal analgesia. New treatments targeting neuroplasticity are emerging.

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Last Updated: Jun 26, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
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Published on: June 23, 2023

Area of Science:

  • Pain Medicine
  • Neuroscience
  • Surgical Research

Background:

  • Chronic post-surgical pain affects millions globally, often stemming from nerve damage during operations.
  • It involves neuroplastic changes and is influenced by surgery type, pain intensity, psychological factors, and genetics (e.g., GCH1 haplotype).

Purpose of the Study:

  • To review the causes, risk factors, and current/emerging management strategies for chronic post-surgical pain.
  • To highlight the importance of preventive measures and novel therapeutic targets.

Main Methods:

  • Literature review of neuroplasticity, pain mechanisms, and clinical studies on post-surgical pain.
  • Analysis of predisposing factors and preventive strategies.
  • Overview of developing therapeutic agents targeting pain sensitization.

Main Results:

  • Chronic post-surgical pain is a significant clinical problem linked to peripheral nerve injury.
  • Key risk factors include surgical approach, pain levels, psychological state, and genetic predispositions.
  • Minimally invasive techniques and multimodal perioperative analgesia are effective preventive measures.

Conclusions:

  • Effective prevention strategies involve surgical technique selection and comprehensive perioperative pain management.
  • Ongoing research focuses on novel treatments for chronic post-surgical pain by targeting underlying neuroplastic mechanisms.