Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pharmacodynamic interaction between caffeine and phenylpropanolamine.

N J Brown1, D Ryder, R A Branch

  • 1Division of Clinical Pharmacology, Vanderbilt University Medical School.

Clinical Pharmacology and Therapeutics
|October 1, 1991
PubMed
Summary

Caffeine and phenylpropanolamine together increase blood pressure additively. This interaction in healthy subjects is not due to pharmacokinetic changes or effects on the sympathetic nervous system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic markers, quality of life (QoL) and value of health (V-He) in advanced biliary cancers (ABC) treated with second-line active symptom control (ASC) alone or ASC with oxaliplatin-5-FU chemotherapy (ASC + FOLFOX) in the randomised phase III, multicentre, open-label ABC-06 clinical trial.

ESMO open·2026
Same author

First national study on genomic profiling of <i>Escherichia coli</i> in United Arab Emirates (UAE) aquatic environments shows diverse Quinolone and Cephalosporin resistance.

Environmental challenges (Amsterdam, Netherlands)·2025
Same author

Long Amplicon Nanopore Sequencing for Dual-Typing RdRp and VP1 Genes of Norovirus Genogroups I and II in Wastewater.

Food and environmental virology·2024
Same author

A new species of <i>Proegernia</i> from the Namba Formation in South Australia and the early evolution and environment of Australian egerniine skinks.

Royal Society open science·2021
Same author

Comparative assessment of live cyprinid and salmonid movement networks in England and Wales.

Preventive veterinary medicine·2020
Same author

The contact structure of Great Britain's salmon and trout aquaculture industry.

Epidemics·2019

Area of Science:

  • Pharmacology
  • Clinical Pharmacology
  • Drug Interactions

Background:

  • Caffeine and phenylpropanolamine are commonly used substances.
  • Understanding their combined effects is crucial for safety.

Purpose of the Study:

  • To investigate the pharmacokinetic and pharmacodynamic interaction between caffeine and phenylpropanolamine.
  • To determine the impact of coadministration on physiological parameters.

Main Methods:

  • Double-blind, placebo-controlled, Latin-square design study.
  • Six healthy subjects on a controlled diet.
  • Administration of phenylpropanolamine, caffeine, or both, with serial measurements of vital signs and plasma/urinary levels.

Main Results:

Related Experiment Videos

  • Coadministration resulted in an additive increase in blood pressure.
  • No pharmacokinetic interaction was identified.
  • Phenylpropanolamine attenuated the epinephrine and renin response to caffeine.

Conclusions:

  • A clinically relevant interaction between caffeine and phenylpropanolamine exists in drug-free subjects.
  • The interaction is not explained by pharmacokinetic changes or involvement of the sympathetic or renin-angiotensin systems.