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Programmed cell death in varicocele-bearing testes.

A Hassan1, E M el-Nashar, T Mostafa

  • 1Department of Dermatology & Andrology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Andrologia
|January 16, 2009
PubMed
Summary

Increased testicular apoptosis, the programmed cell death of germ cells, is observed in men with varicocele, contributing to male infertility and abnormal spermatogenesis.

Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Urology

Background:

  • Accelerated apoptosis plays a key role in male infertility linked to abnormal spermatogenesis.
  • Varicocele is a common cause of male infertility, but its impact on testicular cell apoptosis requires further investigation.

Purpose of the Study:

  • To investigate the occurrence and extent of apoptosis in testicular tissues of men with varicocele.
  • To compare apoptosis levels in fertile and infertile men with varicocele against controls.

Main Methods:

  • Assessment of apoptosis in testicular biopsy specimens using terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling (TUNEL) and electron microscopy.
  • Study included 64 men with varicocele (18 fertile, 46 infertile) and 8 men with obstructive azoospermia as controls.

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Main Results:

  • Apoptotic changes were found in germ cells but not Sertoli cells.
  • Mean tubular apoptotic indices were significantly higher in varicocele patients (fertile and infertile) compared to controls (P < 0.05).
  • Mean Leydig cell apoptotic indices were significantly elevated in infertile varicocele patients compared to fertile controls and obstructive azoospermia controls (P < 0.05).

Conclusions:

  • Testicular apoptosis is significantly increased in men with varicocele, regardless of fertility status.
  • Elevated apoptosis in varicocele-associated testes may contribute to spermatogenic dysfunction and male infertility.