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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Protein Modifications in the RER01:26

Protein Modifications in the RER

Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Updated: Jun 26, 2026

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
11:27

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

Published on: November 8, 2016

SREBPs: SREBP function in glia-neuron interactions.

Nutabi Camargo1, August B Smit, Mark H G Verheijen

  • 1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands.

The FEBS Journal
|January 16, 2009
PubMed
Summary
This summary is machine-generated.

Sterol regulatory element-binding proteins (SREBPs) in glia cells control lipid synthesis, impacting neuron function. This review covers SREBP roles in peripheral nervous system myelination and central nervous system neuronal function.

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Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform (MCP)-based Neuronal Axon and Glia Co-culture System
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Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform (MCP)-based Neuronal Axon and Glia Co-culture System

Published on: October 14, 2012

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Last Updated: Jun 26, 2026

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
11:27

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Published on: November 8, 2016

Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform (MCP)-based Neuronal Axon and Glia Co-culture System
09:34

Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform (MCP)-based Neuronal Axon and Glia Co-culture System

Published on: October 14, 2012

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Mammalian nervous system exhibits autonomous lipid metabolism.
  • Glia cells, including Schwann cells, oligodendrocytes, and astrocytes, are key sites of lipid synthesis.
  • Sterol regulatory element-binding proteins (SREBPs) are known regulators of enzymatic lipid synthesis in the liver.

Purpose of the Study:

  • To propose that SREBP transcription factors in glia cells regulate lipid synthesis essential for glia-neuron interactions.
  • To explore the impact of glia-derived lipids on various neuronal functions.
  • To review the current understanding of SREBP involvement in nervous system physiology.

Main Methods:

  • Literature review and synthesis of existing research.
  • Compilation of data on SREBP function in glial cells.
  • Analysis of glia-neuron interactions mediated by lipid metabolism.

Main Results:

  • SREBPs in Schwann cells are involved in the myelination of peripheral nervous system axons.
  • Astrocyte SREBPs are proposed to play a role in central nervous system neuronal functioning.
  • Glia cell lipid synthesis, regulated by SREBPs, influences neuronal functions.

Conclusions:

  • SREBP transcription factors are critical regulators of lipid metabolism in glial cells.
  • Glia-neuron interactions and neuronal functions are significantly influenced by SREBP-mediated lipid synthesis.
  • Further research into SREBP roles in the nervous system holds potential for understanding and treating neurological disorders.