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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
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Wheezing due to rhinovirus infection in infancy: Bronchial hyperresponsiveness at school age

Anne Kotaniemi-Syrjänen1, Tiina M Reijonen, Kaj Korhonen

  • 1Department of Pediatrics, University of Kuopio, Kuopio University Hospital, Kuopio, Finland. anne.kotaniemi-syrjanen@fimnet.fi

Pediatrics International : Official Journal of the Japan Pediatric Society
|January 16, 2009
PubMed

Insights

Early childhood wheezing hospitalization can lead to lasting lung issues. Predictors include maternal smoking, asthma history, and gender for reduced lung function, while rhinovirus and pet exposure are linked to bronchial hyperresponsiveness.

Area of Science:

  • Pediatric Pulmonology
  • Environmental Health
  • Epidemiology

Background:

  • Early childhood wheezing requiring hospitalization can have long-term respiratory consequences.
  • Factors influencing decreased lung function and bronchial hyperresponsiveness post-wheezing are not fully understood.

Purpose of the Study:

  • To identify predictors of decreased lung function and increased bronchial responsiveness in children after early childhood wheezing hospitalization.
  • To prospectively follow children to assess long-term respiratory outcomes.

Main Methods:

  • Seventy-nine children hospitalized for wheezing before age 2 were followed up.
  • Lung function and bronchial responsiveness to exercise were measured at school age (5.6-8.8 years).

Main Results:

  • At school age, 23% of children had decreased lung function and 13% had increased bronchial responsiveness.
  • Maternal smoking, parental asthma history, and female gender predicted decreased lung function.
  • Rhinovirus-induced wheezing and early pet exposure/sensitization predicted increased bronchial responsiveness.

Conclusions:

  • One-fourth of children experience decreased lung function and one-eighth show increased bronchial responsiveness after early wheezing hospitalization.
  • Specific risk factors identified for long-term respiratory deficits.
  • Early interventions may mitigate these effects, particularly in rhinovirus-related cases.
Abstract

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