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Diffuse systemic sclerosis and related diseases in Thailand
S Panicheewa1, S Chitrabamrung, O Verasertniyom
1Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
Clinical Rheumatology
|June 1, 1991
Summary
This study analyzed 69 patients with systemic sclerosis and related syndromes, finding milder clinical manifestations compared to Western cohorts. Key findings include specific antibody prevalence and increased HLA-DR2 in diffuse systemic sclerosis patients.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Systemic sclerosis (SSc) encompasses diffuse and limited cutaneous forms, overlap syndrome (OS), and primary Raynaud's disease.
- Understanding the clinical spectrum and immunological markers is crucial for patient management.
Purpose of the Study:
- To evaluate clinical manifestations and immunological profiles of SSc and related syndromes.
- To compare findings with existing Western patient series.
Main Methods:
- Retrospective analysis of 115 patients diagnosed between 1977-1987.
- Clinical evaluation and serological testing (antinuclear antibodies, anti-Scl 70, HLA-DR2) of 69 patients.
Main Results:
- Diffuse SSc patients showed high rates of cutaneous, musculoskeletal, and gastrointestinal involvement; renal involvement was less common.
- Antinuclear antibodies (89.7%) and anti-Scl 70 (40.6%) were prevalent. HLA-DR2 was significantly increased (p<0.01) in diffuse SSc.
- Overlap syndrome patients exhibited significant pulmonary and renal system involvement.
Conclusions:
- Patients in this cohort presented with milder clinical manifestations than those reported in Western populations.
- Distinct immunological profiles, including increased HLA-DR2, were observed in diffuse SSc.
- Pulmonary and renal involvement were notable in overlap syndrome patients.