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Related Experiment Video

Updated: Jun 26, 2026

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

Luteal blood flow and luteal function.

Akihisa Takasaki¹, Hiroshi Tamura, Ken Taniguchi

¹Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube, 755-8505 Japan. sugino@yamaguchi-u.ac.jp.

Journal of Ovarian Research

|January 16, 2009

Summary

Improving corpus luteum (CL) blood flow with vitamin-E, L-arginine, or HCG can enhance luteal function in women with luteal phase defect (LFD). These treatments reduced blood flow impedance, leading to better luteal function.

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Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

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Published on: July 4, 2018

Area of Science:

Reproductive Endocrinology
Vascular Biology
Infertility Research

Background:

Corpus luteum (CL) blood flow is crucial for luteal function.
Luteal phase defect (LFD) is characterized by inadequate luteal function.
This study investigates enhancing CL blood flow to improve luteal function in women with LFD.

Purpose of the Study:

To determine if increasing CL blood flow can improve luteal function in women diagnosed with LFD.
To evaluate the efficacy of various interventions in improving CL blood flow and luteal function.

Main Methods:

Transvaginal color-pulsed-Doppler-ultrasonography was used to measure CL blood flow impedance (Resistance Index, RI).
Patients with LFD (serum progesterone < 10 ng/ml) and high CL-RI (≥ 0.51) received vitamin-E, L-arginine, melatonin, or HCG.
Outcomes were assessed by changes in CL-RI and serum progesterone levels.

Main Results:

Vitamin-E improved CL-RI in 83% and serum progesterone in 67% of patients.
L-arginine improved CL-RI in 100% and serum progesterone in 71% of patients.
HCG improved CL-RI in 100% and serum progesterone in 90% of patients; melatonin showed no significant effect.

Conclusions:

Vitamin-E, L-arginine, and HCG treatments effectively improved luteal function by reducing CL blood flow impedance.
Targeting and improving CL blood flow is a viable strategy for managing luteal phase defects.
CL blood flow is a critical determinant of successful luteal function.