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Multicentric reticulohistiocytosis associated with subclinical Sjögren's syndrome
S Shiokawa1, M Shingu, M Nishimura
1Department of Clinical Immunology, Kyushu University, Beppu, Japan.
Abstract:
A case of multicentric reticulohistiocytosis in a 60-year-old Japanese woman associated with subclinical Sjögren's syndrome is presented. The clinical features along with the light microscopic studies are commented. Partial improvement of the skin lesions and tendon sheath swelling was achieved after treatment with cyclophosphamide but the patient's general condition remained unchanged. Taking the rarity of multicentric reticulohistiocytosis into account, coexistence of these two conditions in the present and previously reported cases suggests that an autoimmune mechanism may play a part in the pathogenesis of multicentric reticulohistiocytosis.